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LOOK, FEEL and
THINK YOUNGER with FLAVAY®
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![]() "[A] method for preventing and fighting the harmful biological effects of free radicals...namely...inflammation...[and] collagen degradation"
Flavay® can have a dramatic, visible effect on your skin. The nutrients in Flavay® can be considered as 'collagen vitamins' because they partake in the biosynthesis of collagen and prevent its destruction. Through synergistic action with vitamin C, Flavay® strengthens and rebuilds the bodys natural collagen proteins and has the remarkable ability to reactivate damaged collagen and elastin. Research has demonstrated that Flavay® binds to collagen fibers and realigns them to a more youthful, undamaged form. (The same research also established that common bioflavonoids are completely inactive in this respect.) Flavay® improves the beneficial cross-linking between the amino acids of the fibers that give skin its flexibility and strength while preventing the undesirable cross-linking between amino acids that ages skin like leather. Laboratory tests have demonstrated Flavay’s® ability to reduce degradation of elastin fibers by up to 70 percent.
Flavay’s® ability to reactivate damaged collagen and elastin has great implications for all of your bodys organs. Collagen is required for the normal functioning of the joints, healthy cartilage and bones, smooth gliding surfaces, synovial fluid, normal joint spaces and normal soft tissues surrounding the joints. Collagen is the building block of connective tissue, veins, arteries, ligaments and tendons, and every tissue and organ. Flavay® Improves Circulation to Skin Cells Improved circulation is another reason that Flavay® is an important part of optimally nourishing your skin. Over 60 years of scientific and clinical research establishes that Flavay® actually strengthens collagen in vascular walls and capillaries (the smallest vessels), by making the vessels stronger and more elastic. As we age, the tiny capillaries begin to break down, resulting in diminished blood flow. Fortifying these tiny blood vessels will improve circulation throughout the body, including the skin, delivering blood and nutrients to your skin. Improved circulation results in well-nourished, healthy skinwhich is radiant and more youthful. Inflammations and Edema Flavay® has been licensed and sold in France for treating edema and inflammations since 1950. Puffiness of the eyes and an overall bloated look and feel are examples of edema. It involves the leakage of blood serum into surrounding tissues and Flavay® has shown that it can reduce this leakage by strengthening capillary walls. One of the very first benefits observed and studied by the inventor of Flavay®, Dr. Jack Masquelier, in as early as 1947, was its anti-inflammatory effect. His and others' research demonstrated that Flavay® inhibits the release and synthesis of histamine (which produces accelerated blood flow, dilates capillaries and increases their permeability, thereby leaking plasma into surrounding tissue), a key factor in the promotion of inflammation. Numerous studies have demonstrated that the anti-histamine action of Flavay® is obtained through inhibiting the activity of the enzyme histidine decarboxylase. Research shows that Flavay® may lower the production of histamine with as much as 86% inhibition of histidine decarboxylase. Inflammatory reactions are not limited to edema and other problems typically associated to vascular diseases; the factors that cause inflammation can also cause conditions like allergies, bronchitis, and arthritis. Fortifying Immune Function A strong immune system is the cornerstone of good healthif the immune system is weak, it will eventually affect the other systems of the body. Flavay® can boost your immune system in several important ways. First, by increasing the activity of vitamin C, another important immune booster, Flavay® gives the immune system more ammunition to fight infection. Second, research demonstrates that Flavay® prevents free radical damage to macrophages, a type of white blood cell that generates nitric oxide to destroy bacteria, viruses, and host parasites. Flavay’s® ability to help regulate nitric oxide can profoundly influence the bodys immune functions. As long as nitric oxide is produced in the right amount, it is beneficial to the body, but if nitric oxide is overproduced, the effect can be toxic. When produced by immune cells, nitric oxide fights infection, kills tumor cells, and promotes wound healing. But when produced in excess by immune cells, nitric oxide can trigger chronic inflammation, which can cause arthritis, colitis, and inflammatory bowel disease. Protection Against Brain Aging
Decline in brain function is the most disturbing part of aging. Our brain makes up who we are, our personal identity, and what makes us uniquely human. Our brain must be carefully protected from decline, whether due to aging or disease. Flavay’s® antioxidant protection of brain cells is significant as recent studies have established a connection between free radical damage and cognitive impairment. Research demonstrates that Flavay® helps regulate nitric oxide: a colorless gas produced by many different cells in the body: from endothelial cells on the walls of the arteries to the neurons in the brain to the disease-fighting cells of the immune system. Nitric oxide modulates communication between brain cells and is thereby deeply involved in concentration, learning and memory. And, by controlling the muscular tone of blood vessels, nitric oxide regulates circulation and normalizes blood flow. As long as nitric oxide is produced in the right amount, it is beneficial to the body. Overproduction of nitric oxide, however, promotes production of more free radicals in the brain, which can hamper mental function and cause memory loss and brain aging. Thus, Flavay’s® ability to help maintain the optimal level of nitric oxide profoundly influences brain (and immune) functions. There is also evidence that Flavay® may help the body to regulate enzymes which control the crucial neurotransmitters dopamine and norepinephrine, chemicals that carry messages among brain cells and are involved in excitatory responses. Flavay’s® ability to support healthy blood flow to the brain is also important to brain function. Researchers have shown that decreased blood flow to the brain plays a major role in age-related brain disorders. Flavay® may also help deliver other nutrients to the brain, such as zinc and selenium, which are essential to normal brain function, according to recent research. Preliminary studies have confirmed what many users of this remarkable complex have experienced: striking benefits in improved concentration and mental focus. Synergistic Help for Brain Function, Memory & Acuity Current research demonstrates that antioxidants work synergistically with one another in the body. Flavay Plus® utilizes this dynamic with a synergistic blend of Flavay® and antioxidant vitamins and minerals and phytonutrients; formulated to boost the brain and immune functionsthereby benefiting the whole body.
Flavay® plus phosphatidyl serine: Flavay Plus® is formulated with phosphatidyl serine (Leci-PS®), a complex of amino and fatty acids extracted from soy lecithin, which has proven to be a safe, potentially effective therapeutic agent in treating memory deficit disorders and is an often-used supplement for attention deficit disorders. Phosphatidyl serine has been the subject of many human clinical trials regarding memory loss, mood, cognitive performance, learning ability and stress. Many studies show that phosphatidyl serine can optimize cognition. In the most famous human study, researchers gave 300 mg of phosphatidyl serine a day for 12 weeks to 149 subjects over 50. Various memory and learning tests were administered before and after. The results showed that phosphatidyl serine managed to raise cognitive performance to the levels typical for as much as 12 years younger. Published, double-blind research shows that phosphatidyl serine can also be helpful for depression. Phosphatidyl serine is a phospholipid that is vital to brain cell structure and function. Phospholipids are molecules containing both amino and fatty acid components, which are found in every cell membrane in our bodies. Phosphatidyl serine plays an important role in our neurotransmitter systems, in metabolism levels of the brain, and in maintaining nerve connections in the brain. It appears to help reestablish the normal down-regulation of cortisol secretion that is increased in chronically stressed individuals, and its benefit in dementia and depression may relate to improved brain cell membrane fluidity. In the clinical studies, phosphatidyl serine (100 mg three times daily) has been shown to improve the mood and mental function in those with Parkinsons disease.
Scientific studies have demonstrated that phosphatidyl serine supplementation can increase the output of acetylcholine, the neurotransmitter so important to memory. Clinical trials with elderly patients suffering from memory deficit disorders have shown that adding phosphatidyl serine to the daily diet improved the ability of these patients to think and decreased behavioral disturbances. In other studies, phosphatidyl serine also improved the performance of patients with age-associated memory impairment, a disorder affecting millions of Americans each year. Flavay Plus® utilizes the dynamic interplay between these nutrients and their co-factors in order to provide you and your family with the best that nutritional science has to offer in a convenient, cost effective capsule.
Proven Safety of Flavay® After more than 50 years of human use, no adverse effects have been observed. Furthermore, intensive biological, toxicological, pharmacological and analytical research was conducted for the purpose of registering it as a medicine in France and other countries in Europe. In one study, daily doses of up to 35,000 mg for six months were determined to cause no adverse effects. Flavay® was also clinically tested, in particular for all sorts of symptoms related to venolymphatic insufficiencies (strenghthening veins, improving circulation and reducing edema and inflammations). The spin-off is a goldmine of data: The rigorous testing to meet the standards required by the health ministries of France, Germany and other European countries demonstrate that Flavay® is highly bioavailable, nontoxic, nonallergenic, noncarcinogenic, nonmutagenic, will not cause birth defects, and is completely safe. Dr. Masqueliers unequaled manufacturing process has been conducted for half a century at the very same facilities in France, and under the control of French Pharmaceutical inspection. These time-proven standards serve as a reliable assurance of the quality, consistency, bioavailability and safety of Flavay®. Who can take Flavay®? Everyone, from the very young to elderly. Flavay® has no known contraindications (conditions under which it should not be used). Flavay® is completely safe and nontoxic. In fact, clinical trials have been conducted in which pregnant women (troubled by varicose veins and other circulatory problems in the legs) safely used Flavay®. Safety of Flavay Plus® The essential vitamins and minerals in Flavay Plus® are naturally-derived and completely safe. Flavay Plus® includes phosphatidyl serine, derived from soy lecithin, which has been proven safe in standard toxicology tests. From the large number of human studies conducted, phosphatidyl serine has developed a flawless safety record and proven compatible with a wide array of medications. Consumers need to know that the marketplace is full of imitations, various extracts and derivative forms of Dr. Masqueliers scientifically proven and perfected complex. Unfortunately, many have even used Dr. Masqueliers name and research in unauthorized ways to promote illegitimate products. Flavay® is the name you can trust for the precisely defined active polyphenol
complex proven and perfected by the inventor, Dr. Jack Masquelier, validated
by the French Ministry of Health and documented by a library of research consisting
of many patents and hundreds of scientific papers, articles, doctorate theses,
lectures and presentations. For quality, consistency, bioavailablity and safety,
consumers may rely upon Flavay®. Look, Feel and Think Younger Get the results you want now: Flavay® rebuilds collagen, improves circulation and health in skin cells, and reduces inflammation; boosts the immune system with powerful antioxidant action; and Flavay Plus® can help improve concentration, attention and memoryraising cognitive performance to the levels typical for as much as 12 years younger!
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The effect of pyridoxine hydrochloride on blood serotonin and pyridoxal phosphate contents in hyperactive children. Pediatrics, 1975;55: 437-41. ___. Along with riboflavin, vitamin B-6 deficiency has a primary role in the cause of emotional disorder. British Journal of Psychiatry, 141(1982):271-272. ___. Current data suggest that as many as 20 percent of medically cleared population of outpatient depressives may suffer from a vitamin B-6 deficit. The authors point out that nutrition, diet and vitamin levels have received very little attention in the psychiatric literature. Biological Psychiatry, 9:4 (1984):613-6. ___. Does depressive illness cause vitamin B-6 inadequacy, or vice-versa? Nut Rep Int, 27 (Apr. 1993):867-873. Martineau, J., et al. Vit. B6, magnesium, and combined B6-Mg: therapeutic effects. Bio Psy, 20:467-78, 1985. Dolphin, et al. (eds). Vitamin B6: pyridoxal phosphate. John Wiley & Sons, 1986, chapt. 17. Langseth, L., et al. Glucose tolerance and hyperkinesis. Food and Cosm Toxicology, 16 Aug. 1977. OBrien, C. Answers to ADD. Vitamin Retailer, March 2002. Facino, R.M., et al. Free radical scavenging action and anti-enzyme activities of procyanidines from vitis vinifera. A mechanism for their capillary protective action. Arzneimittelforschung, 44: 592-601, 1994. Kuttan, R., Donnelly, P.V., Di Ferrante, N. Collagen treated with catechin becomes resistant to the action of mammalian collagenase. Experientia, 37: 221-223, 1981. Masquelier, J. Procyanidolic oligomers. J Parums Cosm Arom, 95: 89-97, 1990. Tixier, J.M., et al. Evidence by in vivo and in vitro studies that binding of pycnogenols to elastin affects its rate of degradation by elastases. Biochem Pharmacol, 33: 3933-3939, 1984. Kakegawa, H., et al. Chem. Pharm. Bull. 33:5079, 1985. Harmand, M.F., Blanquet, P. The fate of total flavanolic oligomers extracted from vitus vinifera l. in the rat. European Journal of Drug Metabolism and Pharmaccokinetics. 1978, No. 1 pp. 15-30. Delrieu, P., Ding J., Escande, B., Samain, D. Free-radical scavenging activity of proanthocyanidolic oligomers encapsulated in glycospheres: an in vivo and in vitro study. Cosmetology Department & S Biovectors, Ramonville St. Agne France. pp. 1-9. Meunier, M.T., Villie, F., et al. Inhibition of angiotensin i converting enzyme by flavanolic compounds: in vitro and in vivo studies. Planta Medica, May 26, 1986. pp. 12-15. Barbier, A., et al. Activite angioprotectrice des oligomeres procyanidolques chez lanimal-oedenme de la patte. Sanofi Res Toul Cedex Fr, pp31-40. Barbier, A., et al. Activite angioprotectrice des oligomeres procyanidolques chez lanimal-activite aniagoniste vis-a-vis des mediateurs de linflamation. Sanofi Res Toul Cedex Fr, pp. 31-40. Dubos, C., Durst, G., Hugonot, H. Evolution de la resistance capillaire, spontanement ou artificiellement diminuee par laction dune substance capillaro-toxique chez des personnes agees--action benefique dun agnet actif sur la micro-circulation: lEndotelon. Inform. Therapeut. 1980. pp. 302-305. Dartenuc, J.Y., et al. Resistance capillaire en geriatrie etude dun microangioprotecteur-Endotelon. Bordeaux Med. 13:903-7, 1990. Lagrue, G., Olivier-Martin, F., Grillot, A. Etude des effets des oligomeres du procyanidol sur las resistance capillaire dand lhypertension arterielle et certaines nephropathies. Sen. Hosp. Paris 18-25 Septembre, 1981. Beylot, C., Bioulac, P. Essai therapeutique dun angioprotecteur peripherique, lEndotelon. Actualite Therapeutique Gaz. Med. de France (87)22:2919-24, 1980. Lesbre, F.X., Tigaud, J.D. Effect de lEndotelon sur lindice de fragilite capillaire dan une population specifique: les sujets cirrhotiques. Gaz. Med. de France, (90)24 1983. Sarrat, L. Abord therapeutique des troubles fonctionnels des membres inferieurs par un microangioprotecteur lEndotelon. Bordeaux Med, 11:685-8, 1981. Delacroix, P. Etude en double aveugle de lEndotelon dans linsuffisance veineuse chronique. Therapeutique, la Revue de Medicine, (27-28) Sept. 1981. pp. 1793-1802. Thebaut, J.F, Thebaut, P., Vin, F. Etude de lEndotelon dand les manifestations fonctionnelles de linsuffisance veineuse peripherique-resultats dune etude en double aveugle portant sur 92 patients. Gazette Medicale, (92)1, 1985. pp. 96-100. Chang, W.C., Hsu, F.L. Inhibition of platelet aggregation and arachidonate metabolism in platelets by procyanidins. Prostagland Leukotri Essent Fatty Acids, 38:181-8, 1989. Masquelier, J. Pycnogenols: recent advances in the therapeutical activity of procyanidins. Supplement of Planta Medica, Journal of Medicinal Plant Research and Journal of Natural Products, July 1980 pp. 243-256. Henning, B., et al. Lipid peroxidation and endothelial cell injury: implications in atherosclerosis. Free Rad Path & Med, (4)1988 pp. 99-106. Masquelier, J. Les procyanidols du vin leur role dans lalcoolisme. pp. 88-93. Gazave, J.M. Notions recentes sur les capillaires unpub. bulletin from the Laboratoire De Physiologie Patholigie pp. 26-29. Ruf, J.C. Wine and polyphenols related to platelet aggregation and atherothrombosis. Office International Vigne et du Vin, Nutrition and Health Unit, Paris France; Drugs under Experimental and Clinical Research (Switz.) 25/2-3 (125-131), 1999. Blaszo, G. Gabor, M. Oedema-inhibiting effect of procyanidin. Acta Physiologica Academiae Scientiarum Hungaricae, Tomus 56(2):235-240, 1980. Tayau, M.F, LeFevre, G. Action du leucocyanidol sur lhyalaluronidase. Bull Soc Pharm Bordeaux, 95:132-136, 1956. Lamy, M. Utilization des oligomeres procyanidoliques en gynecologie. Essai Therapeutique Tomel (14) Sept. 2, 1981. pp. 1021-22. Henriet, J.P Une Etude Exemplaire Pour Un Phlebotrope: letude EIVE. Unpub., pp. 77-83. Pfister, A., Simon, M.T., Gazave, J.M. Sites de fixation des oligomeres procyanidoliques dans la paroi des capillaires sanguins du poumon decobaye. Acta Therapeutica (8) 1982. pp. 223-237. Kuttan, R., Donnelly, P., Di Ferrante, N. Collagen treated with (+) -catechin becomes resistant to the action of mammalian collagenase. Laboratory of Connective Tissue Research, Dept. of Biochem. Baylor Col. of Med., Houston TX. 28, May, 1980. Gendre, P., Laparra, J., Barraud, E. Effect protecteur des oligomeres procyanidoliques sur le lathyrisme experimental chez le rat. Ann. Pharm. Francaises, (43)1, 1985 pp. 61-73. Corbe, C., Boissin, J.P., Siou, A. Light vision and chorioretinal circulation. Study of the effect of procyanidolic oligomer (Endotelon). Jn. Fr. Opthalmol, (11)5:453-460, 1988. Boissin, J.P., Corbe C., Siou, A. Chorioretinal circulation and dazzling: use of procyanidol oligomers (Endotelon). Bull Soc Ophtalmol Fr, 88(2):173-4, 177-9, 1988. Proto, F. et al. Electrophysical study of vitis vinifera procyanoside oligomers effects on retinal function in myopic subjects. Ann Ott Clin Ocul, 114:85-93, 1988. Saracco, J.B., Estachy, G.M. Etude d lEndotelon en opthalmologie. Gaz Med de France, 88:2035-2038, 1981. Scharrer, A., Ober, M. Anthocyanosides in the treatment of retinopathies. Klin Monatsbl Augenheilkd, 178:386-389, 1981. Corbe, C., et al. Microangiopathy of the retina. J. Fr. Opthalmol, 11:453, 1988. Verin, M.M., Vildy, A., Maurin, J.F., Retinopathies et O.P.C. Bordeaux Medicale, (16)11. pp. 1467-74, 1978. Soyeux, A. et al. Endotelon. Diabetic retinopathy and hemorheology. Bull Soc Ophtalmol Fr. 87(12):1441-4, 1987. Fromantin, M. Les oligomeres procyanidoliques dans le traitement de la fragilite capillaire et de la retinopathie chez les diabetiques. A propos de 26 cas. Med Int, 16(11):432-434, Nov. 1981. Arne, J.L. Contribution a letude des oligomeres procyanidoliques: Endotelon, dans la retinopathie diabetique (a propos de 30 observations). Gaz. Med. de France, Vol. 89, No. 30, Oct. 8, 1982. Baruch, J. Effect of Endotelon in postoperative edema. Results of a double-blind study versus placebo in 32 female patients. Ann Chir Plast Esthet 29(4):393-5, 1984. Rao, C.N. et al. Influence of bioflavonoids on the collagen metabolism in rats with adjuvantinduced arthritis. Ital J Biochem. 30:54-62, 1981. Gabor, M. Pharmacologic effects of flavonoids on blood vessels. Angiologica, 9:355-374, 1972. Havsteen, B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharmacol, 32:1141-48, 1983. Reimann, H.J., Lorenz, W., Fischer, M., Frölich, R., Meyer, H.J. Berkhauser Verlag, Vol. 7/1, Univ. of Marburg/Lahn, Ger., 1977. Masquelier, J. Action protectrice du vin sur lulcere gastrique. Resultats, p. 61. Amella, M., et al. Inhibition of mast cell histamine release by flavonoids and bioflavonoids. Planta Medica, 5116-20, 1985. Packer, L., et al. The antioxidant miracle: your complete plan. John Wiley & Sons, Inc., 1999. Shaw, R. How [Australian] PycnoGenol [MASQUELIERs®] Helps Sports People. Masquelier, J. Procyanidolic oligomers (leucocyanidins). Parfums Cosmet Arom 95:89-97, 1990. Pecking, A., Desprez-Curely, J.P., Megret, G. Oligomers procyanidoliques (Endotelon) dans le traitement des lymphoedemes post-therepeutiques de members superieurs. Symposium Satellite, Congres International dAngiologie, Toulouse, France, 4-7 Oct. 1989. Fahey, T.D., Pearl M. Hormonal effects of phosphatidylserine during 2 weeks of intense training. Abstract submitted to national meeting of the Amer College of Sports Medicine, June 1998. Monteleone, P., Maj, M., Beinat, L., Natale, M., Kemali, D. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharm 43: 385388, 1992. Fahey, T.D., et al. The hormonal and perceptive effects of phosphatidylserine administration during two weeks of resistive exercise-induced overtraining. Bio of Sport 15(3):135-44, 1998. Laparra, J., Michaud, J. Masquelier, J. Action des oligomeres procyanidoliques sur le cobaye carence en vitamin c. Tavaux Originaux, University of Bordeaux, 1976. Masquelier, J. Action comparee de divers facteurs vitaminiques p sur loxydation de lacide ascorbique par les ions cuivriques. Bull. de la Societe de Chimie Biologique XXXIII (3-4) 1951. pp. 302-304. Masquelier, J. Action comparee de divers facteurs vitaminiques p sur lacide ascorbique-oxydase. Bull. de la Societe de Chimie Biologique XXXIII (3,4) 1951. pp.304-306 Kakegawa, H., Matsumoto, H., Endo, K., Satoh, T., Nonaka, G., Mishioka, I. Inhibitory effects of tannins on hyaluronidase activation and on the degranulation from rat mesentery mast cells. Chem. Pharm. Bull. 33(11)1985. 5079-5082. Reiman, H.J., Lorenz, M., Fischer, R., Frolich, H., Meyer, J. Histamine and acute haemorrhagic lesions in rat gastric mucosa: prevention of stress ulcer formulation by (+)-catechin, an inhibitor of specific histidine decarboxylase in vitro. Dirkhauser Verlag,Vol. 7/1, 1977. Pariente, J.J. Parientl-Amsellem, J. Les oedemes post-traumatoqies chez le sportif: essai controle de lEndothelon. Actualite Therapeutique 90(3) 2/11 1983 pp. 231-235. Masquelier, J., et al. Flavonoids et Pycnogenols Int J Vit Nut Res, (49)3:307-311, 1979. Yu, C. L. et al. Mutagenicity of proanthocyanidins. Food Chem. Toxicol. 25(2):135-9, 1987. Pantaleoni, G.C., Quaglino, D. Univerisity of Aquila Pharmacol-Toxicologica Report, 1971. Laparra, J., et al., Acta Therapeutica, 4:233, 1978. Volkner, Wolfgang Muller, Ewald, Micronucleus assay in bone marrow cells of the mouse with Pycnogenol. Cytotest Cell Research GmbH & Co., projects 143010 & 143021; Feb. 1989. Acute and chronic toxicity tests. International Bio-Research, Inc., Hanover, Germany, 1967-1971. Dumon, M., Michaud, J., Masquelier, J. Proanthocyanidin content in vegetable extracts to be used in the preparation of medicines. Bull. Soc. Pharm. Bordeaux, 129:51-65, 1990. |
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